IN-SILICO MOLECULAR MODELLING, MM/GBSA BINDING FREE ENERGY AND MOLECULAR DYNAMICS SIMULATION STUDY OF NOVEL PYRIDO FUSED IMIDAZO[4,5-C]QUINOLINES AS POTENTIAL ANTI-TUMOR AGENTS

With an alarming increase in the number of cancer patients and a variety of tumors, it is high time for intensive investigation on more efficient and potent anti-tumor agents.Though numerous agents JACKET have enriched the literature, still there exist challenges, with the availability of different targets and possible cross-reactivity.Herein we ha

Vinblastine (VBL) is a major chemotherapeutic drug; however, in some cases, it may cause severe side effects in patients with cancer.Designing a novel VBL pharmaceutical formulation is a crucial and emerging concern Topical Cream among researchers for reducing the use of VBL.This study developed a stimuli-responsive controlled VBL drug release syst

Crossed renal ectopia is a rare congenital malformation.Only 36 cases of crossed renal ectopia with calculus have been recorded in literature, even a few cases of urolithiasis in them have been surgically managed.The majority of cases in literature have been published as single case reports.We conducted Celery Seed a retrospective study of all the

Life history traits determine the organismal abundance within a population and are affected Rattles by the presence of trade-offs that modify relationships between traits.These relationships can vary across different environments either by local adaptation or phenotypic plasticity.Reproductive traits have direct fitness implications and therefore a

Abstract Pancreatic acinar cell carcinoma (PACC) is a rare form of pancreatic cancer that commonly harbors targetable alterations, including activating fusions in the MAPK pathway and loss-of-function (LOF) alterations in DNA damage response/homologous recombination DNA repair-related genes.Here, we describe a patient with PACC harboring both somat